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article 2022 12 pages

Menstrual cycle affects iron homeostasis and hepcidin following interval running exercise in endurance-trained women

Víctor M. Alfaro-Magallanes, Laura Barba-Moreno, Nuria Romero-Parra, Beatriz Rael, Pedro J. Benito, Dorine W. Swinkels, Coby M. Laarakkers, Ángel E. Díaz, Ana B. Peinado, the IronFEMME Study Group

Journal
European Journal of Applied Physiology
DOI
10.1007/s00421-022-05048-5
Publication type
Original Research
Population
endurance-trained women
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Abstract

Purpose

Menstrual cycle phase affects resting hepcidin levels, but such effects on the hepcidin response to exercise are still unclear. Thus, we investigated the hepcidin response to running during three different menstrual cycle phases.

Methods

Twenty-one endurance-trained eumenorrheic women performed three identical interval running protocols during the early-follicular phase (EFP), late-follicular phase (LFP), and mid-luteal phase (MLP). The protocol consisted of 8 × 3 min bouts at 85% of the maximal aerobic speed, with 90-s recovery. Blood samples were collected pre-exercise and at 0 h, 3 h and 24 h post-exercise.

Results

Data presented as mean ± SD. Ferritin were lower in the EFP than the LFP (34.82 ± 16.44 vs 40.90 ± 23.91 ng/ml, p = 0.003), while iron and transferrin saturation were lower during the EFP (58.04 ± 19.70 µg/dl, 14.71 ± 5.47%) compared to the LFP (88.67 ± 36.38 µg/dl, 22.22 ± 9.54%; p 

Description

This study investigates the hepcidin response to running during different menstrual cycle phases.