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article 2024 11 pages

Influence of Menstrual Cycle and Oral Contraceptive Phases on Bone (re)modelling Markers in Response to Interval Running

Isabel Guisado-Cuadrado, Nuria Romero-Parra, Kirsty J. Elliott-Sale, Craig Sale, Ángel E. Díaz, Ana B. Peinado

Journal
Calcified Tissue International
DOI
10.1007/s00223-024-01259-4
Publication type
Original Research
Population
eumenorrheic females and oral contraceptive users
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Abstract

To explore how sex hormone fluctuations may affect bone metabolism, this study aimed to examine P1NP and β-CTX-1 concentrations across the menstrual and oral contraceptive (OC) cycle phases in response to running. 17β-oestradiol, progesterone, P1NP and β-CTX-1 were analysed pre- and post-exercise in eight eumenorrheic females in the early-follicular, late-follicular, and mid-luteal phases, while 8 OC users were evaluated during the withdrawal and active pill-taking phases. The running protocol consisted of 8 × 3min treadmill runs at 85% of maximal aerobic speed. 17β-oestradiol concentrations (pg·ml−1) were lower in early-follicular (47.22 ± 39.75) compared to late-follicular (304.95 ± 235.85;p =  

Description

This study investigates the impact of menstrual and contraceptive phases on bone remodeling markers during exercise.