Abstract
The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150) physically active young men performed the following tests: a) a maximal incremental treadmill test, b) two constant-speed running tests (10 km•h−1 and 12 km•h−1) to determine the running economy, and c) a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km•h−1 (p = 0.232) and 12 km•h−1 (p = 0.259). Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337). These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running.
Citation: Bertuzzi R, Pasqua LA, Bueno S, Lima-Silva AE, Matsuda M, Marquezini M, et al. (2014) Is the COL5A1 rs12722 Gene Polymorphism Associated with Running Economy? PLoS ONE 9(9):
e106581.
https://doi.org/10.1371/journal.pone.0106581
Editor: Mikko Lammi, University of Eastern Finland, Finland
Received: January 30, 2014; Accepted: August 8, 2014; Published: September 4, 2014
Copyright: © 2014 Bertuzzi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: Romulo Bertuzzi is supported by CAPES (grant 23038.000486/2011-15). Leonardo A. Pasqua is supported by FAPESP (grant 2010/13913-6). Salomão Bueno is supported by CAPES (grant 1182744). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Description
This study analyzes the influence of the COL5A1 rs12722 polymorphism on running economy and range of motion.