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article 2025 16 pages

The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity

M. D’Alleva, J. M. Sanz, N. Giovanelli, F. Graniero, L. Mari, R. Spaggiari, D. Sergi, S. Ghisellini, A. Passaro, S. Lazzer

Journal
European Journal of Applied Physiology
DOI
10.1007/s00421-024-05697-8
Publication type
Original Research
Population
trained individuals with obesity
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Abstract

Purpose

The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men.

Methods

Seventeen men (aged 40 ± 6 years; body mass index [BMI] 31.3 ± 2.8 kg m−2, maximal oxygen uptake [V’O2max] 41.5 ± 5.6 ml kg−1 min−1) ran a half, 30 km, or full marathon. Troponin I (cTnI), the n-terminal creatine kinase-myocardial band (CK-MB), pro b-type natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), myoglobin, creatinine (CREA) and the estimated glomerular filtration rate (eGFR) were measured before (T0), immediately after (T1) and 3 days after the race (T2).

Results

The concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (P 

Description

This study examines the effects of prolonged aerobic exercise on various biomarkers in trained obese men.