Abstract
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Abstract
The study aimed to investigate the impact of laboratory-controlled exertional and
exertional-heat stress on concentrations of plasma endogenous endotoxin core
antibody (EndoCAb). Forty-four (males n=26 and females
n=18) endurance trained (V̇ O
2max
56.8min/kg/min) participants completed either: P1–2h
high intensity interval running in 23°C ambient temperature
(Tamb), P2–2h running at 60% V̇
O2max in 35°C Tamb, or P3–3h running
at 60% V̇ O2max in 23°C Tamb.
Blood samples were collected pre- and post-exercise to determine plasma IgM,
IgA, and IgG concentrations. Overall resting pre-exercise levels for plasma Ig
were 173MMU/ml, 37AMU/ml, and 79GMU/ml, respectively.
Plasma IgM concentration did not substantially change pre- to post-exercise in
all protocols, and the magnitude of pre- to post-exercise change for IgM was not
different between protocols (p=0.135). Plasma IgA and IgG increased pre-
to post-exercise in P2 only (p=0.017 and p=0.016, respectively),
but remained within normative range (35–250MU/ml). P2 resulted
in greater disturbances to plasma IgA (p=0.058) and IgG
(p=0.037), compared with P1 and P3. No substantial differences in
pre-exercise and exercise-associated change was observed for EndoCAb between
biological sexes. Exertional and exertional-heat stress resulted in modest
disturbances to systemic EndoCAb responses, suggesting EndoCAb biomarkers
presents a low sensitivity response to controlled-laboratory experimental
designs within exercise gastroenterology.
Key words
gastrointestinal -
epithelium -
endotoxin -
inflammatory cytokine -
immunoglobulin -
exercise
Publication History
Received: 23 January 2022
Accepted: 05 April 2022
Accepted Manuscript online:
14 April 2022
Article published online:
22 July 2022
© 2022. The Author(s). This is an open access article published by
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built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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Description
This study examines the effects of exercise on plasma endotoxin core antibodies in endurance athletes.