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article 2002 9 pages

Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production

Sophie Martin, Emile Andriambeloson, Ken Takeda, Ramaroson Andriantsitohaina

Journal
British Journal of Pharmacology

Abstract

Purpose

Blackcurrant intake increases peripheral blood flow in humans, potentially by anthocyanin-induced vasodilation which may affect substrate delivery and exercise performance. We examined the effects of New Zealand blackcurrant (NZBC) extract on substrate oxidation, cycling time-trial performance and plasma lactate responses following the time-trial in trained cyclists.

Methods

Using a randomized, double-blind, crossover design, 14 healthy men (age: 38 ± 13 years, height: 178 ± 4 cm, body mass: 77 ± 9 kg, \(\dot{V}\)O2max: 53 ± 6 mL kg−1 min−1, mean ± SD) ingested NZBC extract (300 mg day−1 CurraNZ™ containing 105 mg anthocyanin) or placebo (PL, 300 mg microcrystalline cellulose M102) for 7 days (washout 14 days). On day 7, participants performed 30 min of cycling (3 × 10 min at 45, 55 and 65 % \(\dot{V}\)O2max), followed by a 16.1 km time-trial with lactate sampling during a 20-min passive recovery.

Results

NZBC extract increased fat oxidation at 65 % \(\dot{V}\)O2max by 27 % (P 

Description

The study investigates how red wine polyphenols affect calcium mobilization in endothelial cells.